Metabolic syndrome associates with left atrial dysfunction.
Nutr Metab Cardiovasc Dis
; 28(7): 727-734, 2018 07.
Article
en En
| MEDLINE
| ID: mdl-29764718
ABSTRACT
BACKGROUND AND AIMS:
Obesity and metabolic syndrome (MetS) are risk factors of atrial fibrillation (AF), but limited data exist on their effect on left atrial (LA) function. The aim of the study was to evaluate the effects of cardiac, hepatic and intra-abdominal ectopic fat depots and cardiometabolic risk factors on LA function in non-diabetic male subjects. METHODS ANDRESULTS:
Myocardial and hepatic triglyceride contents were measured with 1.5T 1H-magnetic resonance spectroscopy and LA and left ventricular function, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), epicardial and pericardial fat by magnetic resonance imaging (MRI) in 33 men with MetS and 40 men without MetS. LA volumes were assessed using a novel three-chamber orientation based MRI approach. LA ejection fraction (EF) was lower in MetS patients than in the control group (44 ± 7.7% in MetS vs. 49 ± 8.6% in controls, p = 0.013) without LA enlargement, indicating LA dysfunction. LA EF correlated negatively with waist circumference, body mass index, SAT, VAT, fasting serum insulin, and homeostasis model assessment of insulin resistance index, and positively with fasting serum high-density lipoprotein cholesterol. VAT was the best predictor of reduced LA EF.CONCLUSIONS:
MetS associates with subclinical LA dysfunction. Multiple components of MetS are related to LA dysfunction, notably visceral obesity and insulin resistance. Further studies are needed to elucidate the role of mechanical atrial remodeling in the development of AF.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Triglicéridos
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Resistencia a la Insulina
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Función del Atrio Izquierdo
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Síndrome Metabólico
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Grasa Intraabdominal
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Obesidad Abdominal
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Cardiopatías
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Hígado
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Miocardio
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2018
Tipo del documento:
Article