PTEN inhibition enhances angiogenesis in an in vitro model of ischemic injury by promoting Akt phosphorylation and subsequent hypoxia inducible factor-1&#945; upregulation.

Xue, Lixia; Huang, Jiankang; Zhang, Ting; Wang, Xiuzhe; Fu, Jianliang; Geng, Zhi; Zhao, Yuwu; Chen, Hao

PTEN inhibition enhances angiogenesis in an in vitro model of ischemic injury by promoting Akt phosphorylation and subsequent hypoxia inducible factor-1α upregulation.

Xue, Lixia; Huang, Jiankang; Zhang, Ting; Wang, Xiuzhe; Fu, Jianliang; Geng, Zhi; Zhao, Yuwu; Chen, Hao.

Afiliación

Xue L; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Huang J; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Zhang T; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Wang X; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Fu J; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Geng Z; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Zhao Y; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Chen H; Department of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Xuhui District, Shanghai, 20033, China. chenhao_316@aliyun.com.

Metab Brain Dis ; 33(5): 1679-1688, 2018 10.

Article en En | MEDLINE | ID: mdl-29936638

Asunto(s)

Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Fosfohidrolasa PTEN/antagonistas & inhibidores; Proteínas Proto-Oncogénicas c-akt/metabolismo; Oligoelementos/farmacología; Umbral Anaerobio/efectos de los fármacos; Apoptosis/efectos de los fármacos; Movimiento Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Células Cultivadas; Células Endoteliales de la Vena Umbilical Humana; Humanos; Neovascularización Fisiológica/efectos de los fármacos; Fosfohidrolasa PTEN/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Fosforilación/efectos de los fármacos; Transducción de Señal/efectos de los fármacos; Regulación hacia Arriba; Compuestos de Vanadio/farmacología; Factor A de Crecimiento Endotelial Vascular/metabolismo

Palabras clave

Akt; Angiogenesis; Human umbilical vein endothelial cells; Hypoxia inducible factor-1α; Oxygen-glucose deprivation; PTEN

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligoelementos / Fosfohidrolasa PTEN / Proteínas Proto-Oncogénicas c-akt / Subunidad alfa del Factor 1 Inducible por Hipoxia Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article

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