Subpopulation Structure of IFNγ-Producing T Lymphocytes in Patients with Pulmonary Tuberculosis.
Bull Exp Biol Med
; 165(3): 311-314, 2018 Jul.
Article
en En
| MEDLINE
| ID: mdl-30003413
ABSTRACT
The study of subpopulation structure of IFNγ-producing T cells in patients with pulmonary tuberculosis revealed a decrease in the number of CD3+ IFNγ+ cells against the background of significantly increased IFNγ secretion in vitro irrespective of the clinical form of the disease and drug sensitivity of M. tuberculosis, most strongly expressed in case of the disseminated tuberculosis. In patients with infiltrative drug-sensitive and drug-resistant pulmonary tuberculosis, increased number of Th1/Th17 lymphocytes (CD4+ IFNγ+IL-17A+) and, conversely, decreased number of blood γδT cells was detected.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tuberculosis Pulmonar
/
Interferón gamma
/
Tuberculosis Resistente a Múltiples Medicamentos
/
Células TH1
/
Linaje de la Célula
/
Células Th17
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Año:
2018
Tipo del documento:
Article