Smoking is associated with increased disease activity during natalizumab treatment in multiple sclerosis.
Mult Scler
; 25(9): 1298-1305, 2019 08.
Article
en En
| MEDLINE
| ID: mdl-30070595
ABSTRACT
BACKGROUND:
Smoking has been associated with increased multiple sclerosis (MS) risk, disease worsening, and progression in MS patients. Furthermore, interactions between smoking and human leukocyte antigen (HLA) genes have been shown for MS risk. Recently, we found that smoking was associated with an increased relapse rate in interferon-beta-treated relapsing-remitting multiple sclerosis (RRMS) patients.OBJECTIVES:
We examined the association between smoking and relapses in natalizumab-treated RRMS patients. Second, we investigated if an interaction between smoking and HLA-DRB1*1501 or HLA-A*0201 affected the number of relapses during treatment.METHODS:
In this observational cohort study, 355 natalizumab-treated RRMS patients were assessed. Prespecified criteria excluded 62 patients. Clinical data from the starting of treatment to the two-year follow-up visit were collected. Smoking status was obtained by a questionnaire survey. TaqMan allelic discrimination was used for genotyping of tag single-nucleotide polymorphisms (SNPs) for HLA-DRB1*1501 and HLA-A*0201. Negative binomial regression analysis was used to analyze the association between relapse rate and smoking intensity and HLA.RESULTS:
One pack of cigarettes (20 cigarettes) per day during natalizumab treatment increased the relapse rate during treatment with 38% (incidence rate ratio (IRR) = 1.38, 95% confidence interval (CI) 1.08-1.77, p = 0.01). No association or interaction was found between smoking and HLA-DRB1*1501 or HLA-A*0201, respectively.CONCLUSION:
Smoking intensity was significantly associated with the number of relapses during natalizumab treatment.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Esclerosis Múltiple Recurrente-Remitente
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Natalizumab
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Fumar Tabaco
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Factores Inmunológicos
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2019
Tipo del documento:
Article