Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: A cohort study.
J Clin Periodontol
; 45(11): 1326-1335, 2018 11.
Article
en En
| MEDLINE
| ID: mdl-30076615
ABSTRACT
AIM:
To evaluate if non-diabetic subjects with periodontitis respond better than subjects with type 2 diabetes to the treatment protocol of scaling and root planing (SRP), metronidazole (MTZ) and amoxicillin (AMX). MATERIAL ANDMETHODS:
Diabetic and nondiabetic subjects with severe periodontitis received SRP + MTZ (400 mg/thrice a day [TID]) + AMX (500 mg/TID) for 14 days. Subgingival biofilm samples were analyzed by checkerboard DNA-DNA hybridization for 40 bacterial species. Subjects were monitored at baseline, 3, 6 and 12 months post-therapy.RESULTS:
Twenty-nine type 2 diabetics and 29 non-diabetic subjects participated of this study. Of the non-diabetics and diabetics, 68.9% and 75.9%, respectively, reached the clinical endpoint for treatment (≤4 sites with probing depth [PD] ≥5 mm) at 1 year post-therapy (p > 0.05). The diabetic group presented lower mean clinical attachment gain from baseline to 1 year post-therapy and higher mean proportions of the red and orange complexes than the non-diabetic group (p < 0.05).CONCLUSIONS:
Non-diabetic subjects with severe periodontitis did not respond better than type 2 diabetic subjects to the treatment protocol of SRP + MTZ + AMX, both in terms of achieving the clinical endpoint for treatment and of PD improvement. Diabetic subjects exhibited a slightly worse microbiological response and showed a healing process more associated with gingival recession than the non-diabetics.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Periodontitis
/
Placa Dental
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Diabetes Mellitus Tipo 2
Tipo de estudio:
Etiology_studies
/
Guideline
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Incidence_studies
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Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article