Comparison of the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) during carotid artery stenting (CAS) and carotid endarterectomy (CEA).
BMC Neurol
; 18(1): 128, 2018 Aug 29.
Article
en En
| MEDLINE
| ID: mdl-30157791
ABSTRACT
BACKGROUND:
Our aim was to compare the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) in during carotid endarterectomy (CEA) and carotid artery stenting (CAS).METHODS:
In our prospective study, twenty-five patients who were scheduled to undergo CAS were enrolled. We used a matched, historical CEA group as controls. Blood samples were collected at four time points T1 preoperative; T2 60 min after stent insertion; T3 first postoperative morning; and T4 third postoperative morning. Plasma MMP-9 and TIMP-1 levels were measured by ELISA.RESULTS:
In the CEA group, the plasma levels of MMP-9 were significantly elevated at T3 compared to T1. In the CAS group, there was no significant difference in MMP-9 levels in the perioperative period. MMP-9 levels were significantly higher in the T3 samples of the CEA group compared to the CAS group. Significantly lower TIMP-1 levels were measured in both groups at T2 than at T1 in both groups. MMP-9/TIMP-1 at T3 was significantly higher than that at T1 in the CEA group compared to both T1 and the CAS group.CONCLUSIONS:
CAS triggers smaller changes in the MMP-9-TIMP-1 system during the perioperative period, which may correlate with a lower incidence of central nervous system complications. Additional studies as well as cognitive and functional surveys are warranted to determine the clinical relevance of our findings. TRIAL REGISTRATION NIH U.S. National Library of Medicine, Clinicaltrials.gov,NCT03410576, 24.01.2018, Retrospectively registered.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Endarterectomía Carotidea
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Estenosis Carotídea
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Inhibidor Tisular de Metaloproteinasa-1
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Metaloproteinasa 9 de la Matriz
Tipo de estudio:
Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Año:
2018
Tipo del documento:
Article