Acetyl-11-keto-ß-boswellic acid suppresses docetaxel-resistant prostate cancer cells in vitro and in vivo by blocking Akt and Stat3 signaling, thus suppressing chemoresistant stem cell-like properties.

Liu, Yong-Qing; Wang, Shi-Kang; Xu, Qing-Qing; Yuan, Hui-Qing; Guo, Yan-Xia; Wang, Qian; Kong, Feng; Lin, Zhao-Min; Sun, De-Qing; Wang, Rong-Mei; Lou, Hong-Xiang

Liu, Yong-Qing; Wang, Shi-Kang; Xu, Qing-Qing; Yuan, Hui-Qing; Guo, Yan-Xia; Wang, Qian; Kong, Feng; Lin, Zhao-Min; Sun, De-Qing; Wang, Rong-Mei; Lou, Hong-Xiang.

Afiliación

Liu YQ; Department of Pharmacy, The Second Hospital of Shandong University, Jinan, 250033, China.
Wang SK; Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
Xu QQ; Emergency Center, Shandong Provincial Hospital affiliated to Shandong University, Jinan, 250021, China.
Yuan HQ; Department of Dermato-venereology, The Second Hospital of Shandong University, Jinan, 250033, China.
Guo YX; Central Research Laboratory, The Second Hospital of Shandong University, Jinan, 250033, China.
Wang Q; Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, 250012, China.
Kong F; Central Research Laboratory, The Second Hospital of Shandong University, Jinan, 250033, China.
Lin ZM; Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, 250012, China.
Sun DQ; Central Research Laboratory, The Second Hospital of Shandong University, Jinan, 250033, China.
Wang RM; Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, 250012, China.
Lou HX; Central Research Laboratory, The Second Hospital of Shandong University, Jinan, 250033, China.

Acta Pharmacol Sin ; 40(5): 689-698, 2019 May.

Article en En | MEDLINE | ID: mdl-30171201

Asunto(s)

Resistencia a Antineoplásicos/efectos de los fármacos; Neoplasias de la Próstata/tratamiento farmacológico; Proteínas Proto-Oncogénicas c-akt/metabolismo; Factor de Transcripción STAT3/metabolismo; Transducción de Señal/efectos de los fármacos; Triterpenos/uso terapéutico; Animales; Apoptosis/efectos de los fármacos; Línea Celular Tumoral; Docetaxel/farmacología; Relación Dosis-Respuesta a Droga; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Masculino; Ratones Endogámicos C57BL; Células Madre Neoplásicas/efectos de los fármacos; Triterpenos/farmacología

Palabras clave

Akt; Stat3; acetyl-11-keto-ß-boswellic acid; chemoresistant stem cell-like properties; docetaxel-resistance; prostate cancer

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Triterpenos / Transducción de Señal / Resistencia a Antineoplásicos / Proteínas Proto-Oncogénicas c-akt / Factor de Transcripción STAT3 Límite: Animals / Humans / Male Idioma: En Año: 2019 Tipo del documento: Article

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