Extracellular Matrix for Myocardial Repair.
Adv Exp Med Biol
; 1098: 151-171, 2018.
Article
en En
| MEDLINE
| ID: mdl-30238370
ABSTRACT
Multiple strategies have been investigated to restore functional myocardium following injury or disease including the local administration of cytokines or chemokines, stem/progenitor cell therapy, mechanical circulatory support, pharmacologic use, and the use of inductive biomaterials. The use of xenogeneic biologic scaffolds composed of extracellular matrix (ECM) has been shown to facilitate functional restoration of several tissues and organs including the esophagus, skeletal muscle, skin, and myocardium, among others. The present chapter describes the current understanding of specific components of biologic scaffolds composed of ECM, the mechanisms by which ECM bioscaffolds promote constructive cardiac remodeling after injury, determinants of remodeling outcome, and the versatility of ECM as a potential cardiac therapeutic.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ingeniería de Tejidos
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Medicina Regenerativa
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Matriz Extracelular
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Andamios del Tejido
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Corazón
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Procedimientos Quirúrgicos Cardíacos
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Miocardio
Límite:
Animals
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Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article