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Comprehensive Evaluation of the Utility of 20 Endogenous Molecules as Biomarkers of OATP1B Inhibition Compared with Rosuvastatin and Coproporphyrin I.
Barnett, Shelby; Ogungbenro, Kayode; Ménochet, Karelle; Shen, Hong; Humphreys, W Griffith; Galetin, Aleksandra.
Afiliación
  • Barnett S; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, United Kingdom (S.B., K.O., A.G.); Non-Clinical PKPD, UCB, Slough, United Kingdom (K.M.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (H.S., W.G.H.).
  • Ogungbenro K; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, United Kingdom (S.B., K.O., A.G.); Non-Clinical PKPD, UCB, Slough, United Kingdom (K.M.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (H.S., W.G.H.).
  • Ménochet K; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, United Kingdom (S.B., K.O., A.G.); Non-Clinical PKPD, UCB, Slough, United Kingdom (K.M.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (H.S., W.G.H.).
  • Shen H; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, United Kingdom (S.B., K.O., A.G.); Non-Clinical PKPD, UCB, Slough, United Kingdom (K.M.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (H.S., W.G.H.).
  • Humphreys WG; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, United Kingdom (S.B., K.O., A.G.); Non-Clinical PKPD, UCB, Slough, United Kingdom (K.M.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (H.S., W.G.H.).
  • Galetin A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, United Kingdom (S.B., K.O., A.G.); Non-Clinical PKPD, UCB, Slough, United Kingdom (K.M.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (H.S., W.G.H.) Aleksandra
J Pharmacol Exp Ther ; 368(1): 125-135, 2019 01.
Article en En | MEDLINE | ID: mdl-30314992
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores de Hidroximetilglutaril-CoA Reductasas / Coproporfirinas / Transportador 1 de Anión Orgánico Específico del Hígado / Rosuvastatina Cálcica Tipo de estudio: Prognostic_studies Límite: Humans / Male Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores de Hidroximetilglutaril-CoA Reductasas / Coproporfirinas / Transportador 1 de Anión Orgánico Específico del Hígado / Rosuvastatina Cálcica Tipo de estudio: Prognostic_studies Límite: Humans / Male Idioma: En Año: 2019 Tipo del documento: Article