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Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons.
Wamsley, Brie; Jaglin, Xavier Hubert; Favuzzi, Emilia; Quattrocolo, Giulia; Nigro, Maximiliano José; Yusuf, Nusrath; Khodadadi-Jamayran, Alireza; Rudy, Bernardo; Fishell, Gord.
Afiliación
  • Wamsley B; NYU Neuroscience Institute and the Department of Neuroscience and Physiology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
  • Jaglin XH; NYU Neuroscience Institute and the Department of Neuroscience and Physiology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
  • Favuzzi E; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA; Stanley Center at the Broad, 75 Ames Street, Cambridge, MA 02142, USA.
  • Quattrocolo G; NYU Neuroscience Institute and the Department of Neuroscience and Physiology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
  • Nigro MJ; NYU Neuroscience Institute and the Department of Neuroscience and Physiology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
  • Yusuf N; NYU Neuroscience Institute and the Department of Neuroscience and Physiology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA; Stanley Center at t
  • Khodadadi-Jamayran A; Genome Technology Center, Applied Bioinformatics Laboratories, NYU Langone Medical Center, 550 First Avenue, MSB 304, New York, NY 10016, USA.
  • Rudy B; NYU Neuroscience Institute and the Department of Neuroscience and Physiology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
  • Fishell G; NYU Neuroscience Institute and the Department of Neuroscience and Physiology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA; Stanley Center at t
Neuron ; 100(4): 846-859.e7, 2018 11 21.
Article en En | MEDLINE | ID: mdl-30318414
ABSTRACT
Cortical interneurons display a remarkable diversity in their morphology, physiological properties, and connectivity. Elucidating the molecular determinants underlying this heterogeneity is essential for understanding interneuron development and function. We discovered that alternative splicing differentially regulates the integration of somatostatin- and parvalbumin-expressing interneurons into nascent cortical circuits through the cell-type-specific tailoring of mRNAs. Specifically, we identified a role for the activity-dependent splicing regulator Rbfox1 in the development of cortical interneuron-subtype-specific efferent connectivity. Our work demonstrates that Rbfox1 mediates largely non-overlapping alternative splicing programs within two distinct but related classes of interneurons.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Corteza Cerebral / Empalme Alternativo / Factores de Empalme de ARN / Interneuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Corteza Cerebral / Empalme Alternativo / Factores de Empalme de ARN / Interneuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2018 Tipo del documento: Article