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Novel KV7 ion channel openers for the treatment of epilepsy and implications for detrusor tissue contraction.
Seefeld, Mark A; Lin, Hong; Holenz, Joerg; Downie, Dave; Donovan, Brian; Fu, Tingting; Pasikanti, Kishore; Zhen, Wei; Cato, Matthew; Chaudhary, Khuram W; Brady, Pat; Bakshi, Tania; Morrow, Dwight; Rajagopal, Sridharan; Samanta, Swapan Kumar; Madhyastha, Naveena; Kuppusamy, Bharathi Mohan; Dougherty, Robert W; Bhamidipati, Ravi; Mohd, Zainuddin; Higgins, Guy A; Chapman, Mark; Rouget, Céline; Lluel, Philippe; Matsuoka, Yasuji.
Afiliación
  • Seefeld MA; Neuroscience Virtual-Proof-of-Concept Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA, United States. Electronic address: Mark.A.Seefeld@gsk.com.
  • Lin H; Neuroscience Virtual-Proof-of-Concept Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA, United States; Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA, United States.
  • Holenz J; Neuroscience Virtual-Proof-of-Concept Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA, United States.
  • Downie D; Screening Profiling & Mechanistic Biology, Platform Technology Sciences, GlaxoSmithKline, Stevenage, UK.
  • Donovan B; Screening, Profiling and Mechanistic Biology, Platform Technology Sciences, GlaxoSmithKline, Collegeville, PA, United States.
  • Fu T; Mechanistic Safety & Disposition, Product Development and Supply, Platform Technology Sciences, GlaxoSmithKline, Shanghai, China.
  • Pasikanti K; Neuroscience Virtual-Proof-of-Concept Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA, United States.
  • Zhen W; Integrated Biological Platform Sciences, Product Development and Supply, Platform Technology Sciences, GlaxoSmithKline, Shanghai, China.
  • Cato M; In Vitro/In Vivo Translation, Safety Pharmacology, Platform Technology Sciences, GlaxoSmithKline, King of Prussia, PA, United States.
  • Chaudhary KW; In Vitro/In Vivo Translation, Safety Pharmacology, Platform Technology Sciences, GlaxoSmithKline, King of Prussia, PA, United States.
  • Brady P; Screening, Profiling and Mechanistic Biology, Platform Technology Sciences, GlaxoSmithKline, Collegeville, PA, United States.
  • Bakshi T; Pattern Recognition Receptor Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA, United States.
  • Morrow D; Regenerative Medicine Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA, United States.
  • Rajagopal S; Jubilant Biosys, Bangalore, Karnataka, India.
  • Samanta SK; Jubilant Biosys, Bangalore, Karnataka, India.
  • Madhyastha N; Jubilant Biosys, Bangalore, Karnataka, India.
  • Kuppusamy BM; Jubilant Biosys, Bangalore, Karnataka, India.
  • Dougherty RW; Jubilant Discovery Services, Malvern, PA, United States.
  • Bhamidipati R; Jubilant Biosys, Bangalore, Karnataka, India.
  • Mohd Z; Jubilant Biosys, Bangalore, Karnataka, India.
  • Higgins GA; InterVivo Solutions, Toronto, ON, Canada.
  • Chapman M; Icagen, Durham, NC, United States.
  • Rouget C; Urosphere SAS, Toulouse, France.
  • Lluel P; Urosphere SAS, Toulouse, France.
  • Matsuoka Y; Neuroscience Virtual-Proof-of-Concept Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA, United States. Electronic address: Yasuji.Y.Matsuoka@gsk.com.
Bioorg Med Chem Lett ; 28(23-24): 3793-3797, 2018 12 15.
Article en En | MEDLINE | ID: mdl-30327146
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Convulsiones / Epilepsia / Canales de Potasio KCNQ / Anticonvulsivantes Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Convulsiones / Epilepsia / Canales de Potasio KCNQ / Anticonvulsivantes Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article