Characterization of glucose-stimulated insulin release protocols in african green monkeys (Chlorocebus aethiops).
J Med Primatol
; 48(1): 10-21, 2019 02.
Article
en En
| MEDLINE
| ID: mdl-30357856
ABSTRACT
BACKGROUND:
Management of diabetes remains a major health and economic challenge, demanding test systems in which to develop new therapies. These studies assessed different methodologies for determining glucose tolerance in green monkeys.METHODS:
Twenty-eight African green monkeys between 4 and 24 years old underwent single or repeat intravenous glucose tolerance testing (IVGTT), oral glucose tolerance testing (OGTT), and/or graded glucose infusion testing.RESULTS:
Geriatric monkeys exhibited glucose intolerance with impaired glucose-stimulated insulin secretion following IVGTT. Repeat IVGTT and OGTT assessments were inconsistent. Monkeys with low glucose-stimulated insulin secretion after graded glucose infusion exhibited elevated blood glucose levels.CONCLUSION:
IVGTT and graded glucose infusion protocols revealed differences in glucose tolerance among green monkeys at single time points, including age-dependent differences suggestive of shifts in pancreatic beta-cell functional capacity, but care should be applied to study design and the interpretation of data in the setting of longitudinal studies.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Chlorocebus aethiops
/
Secreción de Insulina
/
Prueba de Tolerancia a la Glucosa
Tipo de estudio:
Guideline
/
Observational_studies
Límite:
Animals
Idioma:
En
Año:
2019
Tipo del documento:
Article