Vasoactive intestinal peptide increases apoptosis of hepatocellular carcinoma by inhibiting the cAMP/Bcl-xL pathway.

Hara, Masaki; Takeba, Yuko; Iiri, Taroh; Ohta, Yuki; Ootaki, Masanori; Watanabe, Minoru; Watanabe, Daiki; Koizumi, Satoshi; Otsubo, Takehito; Matsumoto, Naoki

Hara, Masaki; Takeba, Yuko; Iiri, Taroh; Ohta, Yuki; Ootaki, Masanori; Watanabe, Minoru; Watanabe, Daiki; Koizumi, Satoshi; Otsubo, Takehito; Matsumoto, Naoki.

Afiliación

Hara M; Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kawasaki, Japan.
Takeba Y; Department of Pharmacology, St. Marianna University School of Medicine, Kawasaki, Japan.
Iiri T; Department of Pharmacology, St. Marianna University School of Medicine, Kawasaki, Japan.
Ohta Y; Department of Pharmacology, St. Marianna University School of Medicine, Kawasaki, Japan.
Ootaki M; Department of Pharmacology, St. Marianna University School of Medicine, Kawasaki, Japan.
Watanabe M; Experimental Animals Institution, St. Marianna University Graduate School of Medicine, Kawasaki, Japan.
Watanabe D; Department of Pharmacology, St. Marianna University School of Medicine, Kawasaki, Japan.
Koizumi S; Division of Gastroenterological Surgery, St. Marianna University School of Medicine, Kawasaki, Japan.
Otsubo T; Division of Gastroenterological Surgery, St. Marianna University School of Medicine, Kawasaki, Japan.
Matsumoto N; Department of Pharmacology, St. Marianna University School of Medicine, Kawasaki, Japan.

Cancer Sci ; 110(1): 235-244, 2019 Jan.

Article en En | MEDLINE | ID: mdl-30390393

Asunto(s)

Apoptosis/efectos de los fármacos; Carcinoma Hepatocelular/metabolismo; AMP Cíclico/metabolismo; Neoplasias Hepáticas/metabolismo; Péptido Intestinal Vasoactivo/farmacología; Proteína bcl-X/metabolismo; Animales; Carcinoma Hepatocelular/patología; Línea Celular Tumoral; Células Cultivadas; Proteína de Unión a Elemento de Respuesta al AMP Cíclico/metabolismo; Células Hep G2; Humanos; Neoplasias Hepáticas/patología; Fosforilación/efectos de los fármacos; Receptores de Tipo II del Péptido Intestinal Vasoactivo/metabolismo; Receptores de Tipo I del Polipéptido Intestinal Vasoactivo/metabolismo; Transducción de Señal/efectos de los fármacos; Péptido Intestinal Vasoactivo/metabolismo

Palabras clave

Bcl-xL; CREB; apoptosis; hepatocellular carcinoma; vasoactive intestinal peptide

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptido Intestinal Vasoactivo / Apoptosis / AMP Cíclico / Carcinoma Hepatocelular / Proteína bcl-X / Neoplasias Hepáticas Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article

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