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Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma.
Dengler, Hart S; Wu, Xiumin; Peng, Ivan; Rinderknecht, Cornelia H; Kwon, Youngsu; Suto, Eric; Kohli, Pawan Bir; Liimatta, Marya; Barrett, Kathy; Lloyd, Julia; Cain, Gary; Briggs, Mike; Addo, Stephanie; Salmon, Gary; Ubhayakar, Savita; Deshmukh, Gauri; Shahidi-Latham, Sheerin K; Quiason-Huynh, Cristine M; Jackman, Janet; Liu, John; Ray, Nicholas C; Goodacre, Simon C; Johnson, Adam; McKenzie, Brent S; Lee, Wyne P; Zak, Mark; Kenny, Jane R; Ghilardi, Nico.
Afiliación
  • Dengler HS; Department of Immunology Discovery, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wu X; Department of Translational Immunology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Peng I; Department of Translational Immunology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Rinderknecht CH; Department of Translational Immunology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Kwon Y; Department of Translational Immunology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Suto E; Department of Translational Immunology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Kohli PB; Department of Biochemical Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Liimatta M; Department of Biochemical Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Barrett K; Department of Biochemical Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lloyd J; Department of Biology, Charles River Discovery, 8-9 Spire Green Centre, Harlow CM19 5TR, UK.
  • Cain G; Department of Safety Assessment Pathology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Briggs M; Department of Drug Metabolism and Pharmacokinetics, Charles River Discovery, 8-9 Spire Green Centre, Harlow CM19 5TR, UK.
  • Addo S; Department of Drug Metabolism and Pharmacokinetics, Charles River Discovery, 8-9 Spire Green Centre, Harlow CM19 5TR, UK.
  • Salmon G; Department of Biology, Charles River Discovery, 8-9 Spire Green Centre, Harlow CM19 5TR, UK.
  • Ubhayakar S; Department of Drug Metabolism and Pharmacokinetics, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Deshmukh G; Department of Drug Metabolism and Pharmacokinetics, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Shahidi-Latham SK; Department of Drug Metabolism and Pharmacokinetics, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Quiason-Huynh CM; Department of Drug Metabolism and Pharmacokinetics, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Jackman J; Department of Immunology Discovery, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Liu J; Department of Translational Immunology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ray NC; Department of Chemistry, Charles River Discovery, 8-9 Spire Green Centre, Harlow CM19 5TR, UK.
  • Goodacre SC; Department of Chemistry, Charles River Discovery, 8-9 Spire Green Centre, Harlow CM19 5TR, UK.
  • Johnson A; Department of Biochemical Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • McKenzie BS; Department of Translational Immunology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lee WP; Department of Translational Immunology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Zak M; Department of Discovery Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Kenny JR; Department of Safety Assessment Pathology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ghilardi N; Department of Immunology Discovery, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA. ghilardi@gene.com.
Sci Transl Med ; 10(468)2018 11 21.
Article en En | MEDLINE | ID: mdl-30463918
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Asma / Inhibidores de Proteínas Quinasas / Janus Quinasa 1 / Pulmón Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Asma / Inhibidores de Proteínas Quinasas / Janus Quinasa 1 / Pulmón Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2018 Tipo del documento: Article