Report: A comparative study of loratidine physiochemical properties from different brands.
Pak J Pharm Sci
; 31(6): 2569-2574, 2018 Nov.
Article
en En
| MEDLINE
| ID: mdl-30473533
ABSTRACT
Loratidine is a piperidine derivative resemble to azatadine long acting non sedating commonly used for the treatment of allergic condition like watery or itchy eyes, runny nose, chronic urticaria or throat itching. In the present study different brands of loratidine were evaluated for the weight variation, hardness, friability, disintegration time and dissolution. Dissolution release study performed by using paddle method (USP 2) in 900 ml of 0.1N HCl at 50 rpm. The physicochemical of loratidine did not give any variation. By this study we conclude that all parameter for physicochemical properties like weight variation, hardness of tablets, friability, their disintegration time and the dissolution release study for all the brands of loratidine that are available in Karachi meet the British pharmacopoeia (BP) and United State pharmacopoeia (USP) specification for quality control analysis.Weight variation, hardness and friability value requirement was complied by all brands .Disintegration time for all brands was less than 15 minutes complying the BP/USP recommendation. All brands showed more than 80% drug release within 45 minutes. The present findings suggest that almost all the brands of loratidine meet the BP/USP specification for QC analysis.
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Banco de datos:
MEDLINE
Asunto principal:
Medicamentos Genéricos
/
Loratadina
/
Antagonistas de los Receptores Histamínicos H1 no Sedantes
Tipo de estudio:
Guideline
Idioma:
En
Año:
2018
Tipo del documento:
Article