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Ceratinadins E and F, New Bromotyrosine Alkaloids from an Okinawan Marine Sponge Pseudoceratina sp.
Kurimoto, Shin-Ichiro; Ohno, Taito; Hokari, Rei; Ishiyama, Aki; Iwatsuki, Masato; Omura, Satoshi; Kobayashi, Jun'ichi; Kubota, Takaaki.
Afiliación
  • Kurimoto SI; Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan. kurimoto@ac.shoyaku.ac.jp.
  • Ohno T; Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan. b13031@ug.shoyaku.ac.jp.
  • Hokari R; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. hokari@lisci.kitasato-u.ac.jp.
  • Ishiyama A; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. ishiyama@lisci.kitasato-u.ac.jp.
  • Iwatsuki M; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. iwatuki@lisci.kitasato-u.ac.jp.
  • Omura S; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. omuras@insti.kitasato-u.ac.jp.
  • Kobayashi J; Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. jkobay@pharm.hokudai.ac.jp.
  • Kubota T; Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan. kubota@ac.shoyaku.ac.jp.
Mar Drugs ; 16(12)2018 11 23.
Article en En | MEDLINE | ID: mdl-30477099
ABSTRACT
Two new bromotyrosine alkaloids, ceratinadins E (1) and F (2), were isolated from an Okinawan marine sponge Pseudoceratina sp. as well as a known bromotyrosine alkaloid, psammaplysin F (3). The gross structures of 1 and 2 were elucidated on the basis of spectroscopic data. The absolute configurations of 1 and 2 were assigned by comparison of the NMR and ECD data with those of a known related bromotyrosine alkaloid, psammaplysin A (4). Ceratinadins E (1) and F (2) are new bromotyrosine alkaloids possessing an 8,10-dibromo-9-methoxy-1,6-dioxa-2-azaspiro[4.6]undeca-2,7,9-trien-4-ol unit with two or three 11-N-methylmoloka'iamine units connected by carbonyl groups, respectively. Ceratinadin E (1) exhibited antimalarial activities against a drug-resistant and a drug-sensitive strains of Plasmodium falciparum (K1 and FCR3 strains, respectively).
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Plasmodium falciparum / Poríferos / Tirosina / Alcaloides / Antimaláricos Límite: Animals Idioma: En Año: 2018 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Plasmodium falciparum / Poríferos / Tirosina / Alcaloides / Antimaláricos Límite: Animals Idioma: En Año: 2018 Tipo del documento: Article