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An accurate TMT-based approach to quantify and model lysine susceptibility to conjugation via N-hydroxysuccinimide esters in a monoclonal antibody.
Hill, Jennifer J; Tremblay, Tammy-Lynn; Corbeil, Christopher R; Purisima, Enrico O; Sulea, Traian.
Afiliación
  • Hill JJ; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Dr, Ottawa, ON, K1A 0R6, Canada. jennifer.hill@nrc-cnrc.gc.ca.
  • Tremblay TL; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Dr, Ottawa, ON, K1A 0R6, Canada.
  • Corbeil CR; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Ave, Montreal, QC, H4P 2R2, Canada.
  • Purisima EO; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Ave, Montreal, QC, H4P 2R2, Canada.
  • Sulea T; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Ave, Montreal, QC, H4P 2R2, Canada. traian.sulea@nrc-cnrc.gc.ca.
Sci Rep ; 8(1): 17680, 2018 12 05.
Article en En | MEDLINE | ID: mdl-30518942
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Succinimidas / Inmunoconjugados / Lisina / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Succinimidas / Inmunoconjugados / Lisina / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Idioma: En Año: 2018 Tipo del documento: Article