AKT activator SC79 protects hepatocytes from TNF-&#945;-mediated apoptosis and alleviates d-Gal/LPS-induced liver injury.

Jing, Zhen-Tang; Liu, Wei; Xue, Chao-Rong; Wu, Shu-Xiang; Chen, Wan-Nan; Lin, Xin-Jian; Lin, Xu

AKT activator SC79 protects hepatocytes from TNF-α-mediated apoptosis and alleviates d-Gal/LPS-induced liver injury.

Jing, Zhen-Tang; Liu, Wei; Xue, Chao-Rong; Wu, Shu-Xiang; Chen, Wan-Nan; Lin, Xin-Jian; Lin, Xu.

Afiliación

Jing ZT; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University , Fuzhou , China.
Liu W; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University , Fuzhou , China.
Xue CR; Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University , Fuzhou , China.
Wu SX; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University , Fuzhou , China.
Chen WN; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University , Fuzhou , China.
Lin XJ; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University , Fuzhou , China.
Lin X; Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University , Fuzhou , China.

Am J Physiol Gastrointest Liver Physiol ; 316(3): G387-G396, 2019 03 01.

Article en En | MEDLINE | ID: mdl-30629471

Asunto(s)

Apoptosis/efectos de los fármacos; Enfermedad Hepática Crónica Inducida por Sustancias y Drogas/tratamiento farmacológico; Hepatocitos/efectos de los fármacos; Proteínas Proto-Oncogénicas c-akt/efectos de los fármacos; Factor de Necrosis Tumoral alfa/metabolismo; Animales; Enfermedad Hepática Crónica Inducida por Sustancias y Drogas/patología; Hepatocitos/metabolismo; Humanos; Lipopolisacáridos/farmacología; Hígado/efectos de los fármacos; Hígado/lesiones; Hígado/metabolismo; Ratones Endogámicos C57BL; Fosfatidilinositol 3-Quinasas/metabolismo; Sustancias Protectoras/farmacología; Transducción de Señal/efectos de los fármacos; Factor de Necrosis Tumoral alfa/efectos de los fármacos

Palabras clave

AKT activation; Akt activator SC79; TNF-α; TNFR1; hepatocyte apoptosis; liver injury

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factor de Necrosis Tumoral alfa / Apoptosis / Hepatocitos / Proteínas Proto-Oncogénicas c-akt / Enfermedad Hepática Crónica Inducida por Sustancias y Drogas Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article

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