On-target and off-target effects of novel orthosteric and allosteric activators of GPR84.

Mancini, Sarah J; Mahmud, Zobaer Al; Jenkins, Laura; Bolognini, Daniele; Newman, Robert; Barnes, Matt; Edye, Michelle E; McMahon, Stephen B; Tobin, Andrew B; Milligan, Graeme

Mancini, Sarah J; Mahmud, Zobaer Al; Jenkins, Laura; Bolognini, Daniele; Newman, Robert; Barnes, Matt; Edye, Michelle E; McMahon, Stephen B; Tobin, Andrew B; Milligan, Graeme.

Afiliación

Mancini SJ; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
Mahmud ZA; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
Jenkins L; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
Bolognini D; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
Newman R; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, United Kingdom.
Barnes M; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, United Kingdom.
Edye ME; Wolfson Centre for Age-Related Diseases, King's College London, London, SE1 1UL, United Kingdom.
McMahon SB; Wolfson Centre for Age-Related Diseases, King's College London, London, SE1 1UL, United Kingdom.
Tobin AB; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
Milligan G; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, G12 8QQ, United Kingdom. Graeme.Milligan@glasgow.ac.uk.

Sci Rep ; 9(1): 1861, 2019 02 12.

Article en En | MEDLINE | ID: mdl-30755705

Asunto(s)

Receptores Acoplados a Proteínas G/química; Sitio Alostérico; Animales; Sitios de Unión; Células de la Médula Ósea/metabolismo; Proteínas de Unión al GTP/metabolismo; Células HEK293; Humanos; Fibrosis Pulmonar Idiopática/metabolismo; Ligandos; Lipopolisacáridos/metabolismo; Ratones; Ratones Noqueados; Neutrófilos/metabolismo; Células RAW 264.7; Receptores Acoplados a Proteínas G/agonistas; Células THP-1

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores Acoplados a Proteínas G Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores Acoplados a Proteínas G Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article