Dysregulation of T Follicular Helper Cells in Lupus.
J Immunol
; 202(6): 1649-1658, 2019 03 15.
Article
en En
| MEDLINE
| ID: mdl-30833421
ABSTRACT
Although multiple and overlapping mechanisms are ultimately responsible for the immunopathology observed in patients with systemic lupus erythematosus, autoreactive Abs secreted by autoreactive plasma cells (PCs) are considered to play a critical role in disease progression and immunopathology. Given that PCs derive from the germinal centers (GC), long-term dysregulated GC reactions are often associated with the development of spontaneous autoantibody responses and immunopathology in systemic lupus erythematosus patients. In this review, we summarize the emerging evidence concerning the roles of T follicular helper cells in regulating pathogenic GC and autoreactive PC responses in lupus.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T Colaboradores-Inductores
/
Lupus Eritematoso Sistémico
Límite:
Animals
/
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article