Mechanism of frataxin "bypass" in human iron-sulfur cluster biosynthesis with implications for Friedreich's ataxia.

Das, Deepika; Patra, Shachin; Bridwell-Rabb, Jennifer; Barondeau, David P

Das, Deepika; Patra, Shachin; Bridwell-Rabb, Jennifer; Barondeau, David P.

Afiliación

Das D; From the Department of Chemistry, Texas A & M University, College Station, Texas 77842.
Patra S; From the Department of Chemistry, Texas A & M University, College Station, Texas 77842.
Bridwell-Rabb J; From the Department of Chemistry, Texas A & M University, College Station, Texas 77842.
Barondeau DP; From the Department of Chemistry, Texas A & M University, College Station, Texas 77842 barondeau@tamu.edu.

J Biol Chem ; 294(23): 9276-9284, 2019 06 07.

Article en En | MEDLINE | ID: mdl-30975898

Asunto(s)

Ataxia de Friedreich/patología; Proteínas de Unión a Hierro/metabolismo; Regulación Alostérica; Liasas de Carbono-Azufre/metabolismo; Ataxia de Friedreich/metabolismo; Glutarredoxinas/metabolismo; Humanos; Proteínas de Unión a Hierro/genética; Proteínas Hierro-Azufre/genética; Proteínas Hierro-Azufre/metabolismo; Cinética; Mutagénesis Sitio-Dirigida; Unión Proteica; Frataxina

Palabras clave

ISCU2 M140I; analytical ultracentrifugation; circular dichroism (CD); cysteine labeling; enzyme kinetics; fluorescence anisotropy; ironsulfur assembly; ironsulfur protein; mitochondrial disease; neurodegeneration

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ataxia de Friedreich / Proteínas de Unión a Hierro Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google