Serum Vitamin D Levels and Alopecia Areata- A Hospital Based Case-Control Study from North-India.
Int J Trichology
; 11(2): 49-57, 2019.
Article
en En
| MEDLINE
| ID: mdl-31007473
ABSTRACT
BACKGROUND:
Alopecia areata (AA) is an autoimmune disease which is characterized by hair loss and affects any hair-bearing area. Low levels of Vitamin D have been implicated in a variety of autoimmune diseases. This study was conducted to assess the levels of Vitamin D in patients with AA and its correlation with severity, pattern, and extent of the disease. MATERIALS ANDMETHODS:
This hospital-based study included 135 cases with AA and 135 age- and sex-matched controls. AA cases were grouped according to the severity, pattern, and extent of the disease. The levels of Vitamin D were assessed and compared between cases and controls and among different groups of cases. The data were analyzed, and the correlation was derived.RESULTS:
The more number of patients from the case group had deficient and insufficient levels of Vitamin D as compared to controls, the difference being statistically significant (P = 0.01). A highly significant difference was found in mean Vitamin D levels between cases and controls (P = 0.0004). A negative correlation was found between Vitamin D levels and severity of AA as accessed by SALT score. A negative correlation was also found between Vitamin D levels with pattern and extent of the disease.CONCLUSION:
Vitamin D deficiency may be one of the factors having a role either in etiopathogenesis or exacerbation of AA. Supplementation of Vitamin D as a treatment modality may improve the clinical outcome of AA.
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Banco de datos:
MEDLINE
Tipo de estudio:
Observational_studies
Idioma:
En
Año:
2019
Tipo del documento:
Article