Diverse developmental strategies of X chromosome dosage compensation in eutherian mammals.
Int J Dev Biol
; 63(3-4-5): 223-233, 2019.
Article
en En
| MEDLINE
| ID: mdl-31058299
ABSTRACT
In eutherian mammals, dosage compensation arose to balance X-linked gene expression between sexes and relatively to autosomal gene expression in the evolution of sex chromosomes. Dosage compensation occurs in early mammalian development and comprises X chromosome upregulation and inactivation that are tightly coordinated epigenetic processes. Despite a uniform principle of dosage compensation, mechanisms of X chromosome inactivation and upregulation demonstrate a significant variability depending on sex, developmental stage, cell type, individual, and mammalian species. The review focuses on relationships between X chromosome inactivation and upregulation in mammalian early development.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Roedores
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Inactivación del Cromosoma X
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ARN Largo no Codificante
Límite:
Animals
Idioma:
En
Año:
2019
Tipo del documento:
Article