Helicobacter pylori pediatric infection changes FcεRI expression in dendritic cells and Treg profile in vivo and in vitro.
Microbes Infect
; 21(10): 449-455, 2019 12.
Article
en En
| MEDLINE
| ID: mdl-31128278
ABSTRACT
H. pylori infection shows an inverse relationship with allergies. Dendritic cells regulate mucosal immune responses including the induction of T regulatory cells which are fundamental in Helicobacter pylori-induced dampening of allergies. In this respect expression of high-affinity IgE receptor (FcεRI) has been associated with a regulatory dendritic cell profile. Therefore we aimed to evaluate possible mechanisms by which H. pylori infection might modify atopy in pediatric patients. Here we show that H. pylori-infected children exhibited both increased expression of FcεRI on peripheral myeloid and plasmacytoid dendritic cells and higher levels of Foxp3 and Latency Associated Peptide on T regulatory cells. Moreover, exposure to H. pylori drove increased FcεRI expression and IL-10 secretion by both pediatric H. pylori-exposed monocyte derived dendritic cells and T cells. Finally, we show a positive correlation between expression of FcεRI in circulating myeloid DCs and total Treg cells, suggesting that in children, H. pylori infection may have a modulating role in atopy, mediated by both altered surface expression of FcεRI on children's DC and an increased T regulatory cell profile.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Dendríticas
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Regulación de la Expresión Génica
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Helicobacter pylori
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Infecciones por Helicobacter
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Receptores de IgE
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Linfocitos T Reguladores
Límite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Año:
2019
Tipo del documento:
Article