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Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members.
Yang, Yanli; Yeh, Sherry H; Madireddi, Shravan; Matochko, Wadim L; Gu, Chen; Pacheco Sanchez, Patricia; Ultsch, Mark; De Leon Boenig, Gladys; Harris, Seth F; Leonard, Brandon; Scales, Suzie J; Zhu, Jing W; Christensen, Erin; Hang, Julie Q; Brezski, Randall J; Marsters, Scot; Ashkenazi, Avi; Sukumaran, Siddharth; Chiu, Henry; Cubas, Rafael; Kim, Jeong M; Lazar, Greg A.
Afiliación
  • Yang Y; a Departments of Antibody Engineering, Genentech Inc ., South San Francisco , CA , USA.
  • Yeh SH; b Biochemical and Cellular Pharmacology, Genentech Inc ., South San Francisco , CA , USA.
  • Madireddi S; c Cancer Immunology, Genentech Inc ., South San Francisco , CA , USA.
  • Matochko WL; a Departments of Antibody Engineering, Genentech Inc ., South San Francisco , CA , USA.
  • Gu C; d Protein Chemistry, Genentech Inc ., South San Francisco , CA , USA.
  • Pacheco Sanchez P; e Translational Oncology, Genentech Inc ., South San Francisco , CA , USA.
  • Ultsch M; f Structural Biology, Genentech Inc ., South San Francisco , CA , USA.
  • De Leon Boenig G; f Structural Biology, Genentech Inc ., South San Francisco , CA , USA.
  • Harris SF; f Structural Biology, Genentech Inc ., South San Francisco , CA , USA.
  • Leonard B; a Departments of Antibody Engineering, Genentech Inc ., South San Francisco , CA , USA.
  • Scales SJ; g Molecular Biology, Genentech Inc ., South San Francisco , CA , USA.
  • Zhu JW; c Cancer Immunology, Genentech Inc ., South San Francisco , CA , USA.
  • Christensen E; d Protein Chemistry, Genentech Inc ., South San Francisco , CA , USA.
  • Hang JQ; d Protein Chemistry, Genentech Inc ., South San Francisco , CA , USA.
  • Brezski RJ; a Departments of Antibody Engineering, Genentech Inc ., South San Francisco , CA , USA.
  • Marsters S; c Cancer Immunology, Genentech Inc ., South San Francisco , CA , USA.
  • Ashkenazi A; c Cancer Immunology, Genentech Inc ., South San Francisco , CA , USA.
  • Sukumaran S; h Pre-Clinical and Translational Pharmacokinetics, Genentech Inc ., South San Francisco , CA , USA.
  • Chiu H; b Biochemical and Cellular Pharmacology, Genentech Inc ., South San Francisco , CA , USA.
  • Cubas R; e Translational Oncology, Genentech Inc ., South San Francisco , CA , USA.
  • Kim JM; c Cancer Immunology, Genentech Inc ., South San Francisco , CA , USA.
  • Lazar GA; a Departments of Antibody Engineering, Genentech Inc ., South San Francisco , CA , USA.
MAbs ; 11(6): 996-1011, 2019.
Article en En | MEDLINE | ID: mdl-31156033
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Linfocitos T / Transducción de Señal / Ligando OX40 / Receptores del Ligando Inductor de Apoptosis Relacionado con TNF / Recubrimiento Inmunológico / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Linfocitos T / Transducción de Señal / Ligando OX40 / Receptores del Ligando Inductor de Apoptosis Relacionado con TNF / Recubrimiento Inmunológico / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article