A DNA vaccine expressing an optimized secreted FAP&#945; induces enhanced anti-tumor activity by altering the tumor microenvironment in a murine model of breast cancer.

Geng, Fei; Guo, Jie; Guo, Qian-Qian; Xie, Yu; Dong, Ling; Zhou, Yi; Liu, Chen-Lu; Yu, Bin; Wu, Hui; Wu, Jia-Xin; Zhang, Hai-Hong; Kong, Wei; Yu, Xiang-Hui

A DNA vaccine expressing an optimized secreted FAPα induces enhanced anti-tumor activity by altering the tumor microenvironment in a murine model of breast cancer.

Geng, Fei; Guo, Jie; Guo, Qian-Qian; Xie, Yu; Dong, Ling; Zhou, Yi; Liu, Chen-Lu; Yu, Bin; Wu, Hui; Wu, Jia-Xin; Zhang, Hai-Hong; Kong, Wei; Yu, Xiang-Hui.

Afiliación

Geng F; National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, PR China.
Guo J; National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, PR China.
Guo QQ; National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, PR China.
Xie Y; National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, PR China.
Dong L; National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, PR China.
Zhou Y; National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, PR China.
Liu CL; National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, PR China.
Yu B; National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, PR China.
Wu H; National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, PR China.
Wu JX; National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, PR China.
Zhang HH; National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, PR China. Electronic address: Zhanghh@jlu.edu.cn.
Kong W; National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, PR China.
Yu XH; National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, PR China.

Vaccine ; 37(31): 4382-4391, 2019 07 18.

Article en En | MEDLINE | ID: mdl-31202521

Asunto(s)

Neoplasias de la Mama/etiología; Neoplasias de la Mama/patología; Gelatinasas/genética; Gelatinasas/inmunología; Expresión Génica; Proteínas de la Membrana/genética; Proteínas de la Membrana/inmunología; Serina Endopeptidasas/genética; Serina Endopeptidasas/inmunología; Microambiente Tumoral; Vacunas de ADN/genética; Vacunas de ADN/inmunología; Animales; Neoplasias de la Mama/terapia; Vacunas contra el Cáncer/genética; Vacunas contra el Cáncer/inmunología; Vacunas contra el Cáncer/uso terapéutico; Línea Celular Tumoral; Modelos Animales de Enfermedad; Endopeptidasas; Femenino; Humanos; Inmunogenicidad Vacunal; Ratones; Plásmidos/genética; Resultado del Tratamiento; Microambiente Tumoral/genética; Microambiente Tumoral/inmunología; Vacunas de ADN/uso terapéutico; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Cancer immunotherapy; Cancer-associated fibroblast; DNA vaccine; FAPα; Myeloid-derived suppressor cell; Tumour microenvironment

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Serina Endopeptidasas / Expresión Génica / Gelatinasas / Vacunas de ADN / Microambiente Tumoral / Proteínas de la Membrana Límite: Animals / Female / Humans Idioma: En Año: 2019 Tipo del documento: Article

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