A genetic epidemiological study in British adults and older adults shows a high heritability of the combined indicator of vitamin B12 status (cB12) and connects B12 status with utilization of mitochondrial substrates and energy metabolism.

Dalmia, Anupriya; Dib, Marie-Joe; Maude, Hannah; Harrington, Dominic J; Sobczynska-Malefora, Agata; Andrew, Toby; Ahmadi, Kourosh R

A genetic epidemiological study in British adults and older adults shows a high heritability of the combined indicator of vitamin B₁₂ status (cB₁₂) and connects B₁₂ status with utilization of mitochondrial substrates and energy metabolism.

Dalmia, Anupriya; Dib, Marie-Joe; Maude, Hannah; Harrington, Dominic J; Sobczynska-Malefora, Agata; Andrew, Toby; Ahmadi, Kourosh R.

Afiliación

Dalmia A; Department of Nutritional Sciences, School of Biosciences and Medicine, University of Surrey, UK; Department of Genomics of Common Disease, Imperial College, London, UK.
Dib MJ; Department of Nutritional Sciences, School of Biosciences and Medicine, University of Surrey, UK.
Maude H; Department of Genomics of Common Disease, Imperial College, London, UK.
Harrington DJ; The Nutristasis Unit, Viapath, St. Thomas' Hospital, London, UK; King's College London, UK.
Sobczynska-Malefora A; The Nutristasis Unit, Viapath, St. Thomas' Hospital, London, UK; King's College London, UK.
Andrew T; Department of Genomics of Common Disease, Imperial College, London, UK.
Ahmadi KR; Department of Nutritional Sciences, School of Biosciences and Medicine, University of Surrey, UK. Electronic address: k.ahmadi@surrey.ac.uk.

J Nutr Biochem ; 70: 156-163, 2019 08.

Article en En | MEDLINE | ID: mdl-31203192

Asunto(s)

Metabolismo Energético; Ferredoxina-NADP Reductasa/genética; Errores Innatos del Metabolismo/genética; Mitocondrias/metabolismo; Tioléster Hidrolasas/genética; Vitamina B 12/metabolismo; Adulto; Anciano; Anciano de 80 o más Años; Transferasas Alquil y Aril/genética; Biomarcadores/metabolismo; Femenino; Estudio de Asociación del Genoma Completo; Homocisteína/sangre; Humanos; Masculino; Ácido Metilmalónico/sangre; Metilmalonil-CoA Mutasa/genética; Persona de Mediana Edad; Epidemiología Molecular; Polimorfismo de Nucleótido Simple; Transcobalaminas/metabolismo; Valina/metabolismo

Palabras clave

Genetic association study; Heritability; Mitochondrial function; Twin studies; Vitamin B(12); cB(12)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tioléster Hidrolasas / Vitamina B 12 / Metabolismo Energético / Ferredoxina-NADP Reductasa / Errores Innatos del Metabolismo / Mitocondrias Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article

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