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SAR optimization studies on modified salicylamides as a potential treatment for acute myeloid leukemia through inhibition of the CREB pathway.
Chae, Hee-Don; Cox, Nick; Capolicchio, Samanta; Lee, Jae Wook; Horikoshi, Naoki; Kam, Sharon; Ng, Andrew A; Edwards, Jeffrey; Butler, Tae-León; Chan, Justin; Lee, Yvonne; Potter, Garrett; Capece, Mark C; Liu, Corey W; Wakatsuki, Soichi; Smith, Mark; Sakamoto, Kathleen M.
Afiliación
  • Chae HD; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Cox N; Medicinal Chemistry Knowledge Center, Stanford ChEM-H, Stanford, CA, USA; Presently at Novo Nordisk Research Center Seattle, Inc., USA.
  • Capolicchio S; Medicinal Chemistry Knowledge Center, Stanford ChEM-H, Stanford, CA, USA.
  • Lee JW; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Horikoshi N; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
  • Kam S; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Ng AA; Medicinal Chemistry Knowledge Center, Stanford ChEM-H, Stanford, CA, USA.
  • Edwards J; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Butler TL; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Chan J; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Lee Y; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Potter G; Medicinal Chemistry Knowledge Center, Stanford ChEM-H, Stanford, CA, USA.
  • Capece MC; Department of Chemistry, Stanford University, Stanford, CA, USA.
  • Liu CW; Macromolecular Structure Knowledge Center, Stanford ChEM-H, Stanford, CA, USA.
  • Wakatsuki S; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA; BioSciences Division, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
  • Smith M; Medicinal Chemistry Knowledge Center, Stanford ChEM-H, Stanford, CA, USA. Electronic address: mxsmith@stanford.edu.
  • Sakamoto KM; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: kmsakamo@stanford.edu.
Bioorg Med Chem Lett ; 29(16): 2307-2315, 2019 08 15.
Article en En | MEDLINE | ID: mdl-31253529
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Salicilamidas / Inhibidores Enzimáticos / Proteína de Unión a CREB / Antineoplásicos Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Salicilamidas / Inhibidores Enzimáticos / Proteína de Unión a CREB / Antineoplásicos Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article