Role of matrix metalloproteinases in the pathogenesis of intracranial aneurysms.
Neurosurg Focus
; 47(1): E4, 2019 07 01.
Article
en En
| MEDLINE
| ID: mdl-31261127
ABSTRACT
Intracranial aneurysms (IAs) are a result of complex interactions between biochemical and mechanical forces and can lead to significant morbidity if they rupture and cause subarachnoid hemorrhage. This review explores the role of matrix metalloproteinases (MMPs) in the pathogenesis and progression of IAs. In addition to providing a review of the normal function of MMPs, it is intended to explore the interaction between inflammation and abnormal blood flow and the resultant pathological vascular remodeling processes seen in the development and rupture of IAs. Also reviewed is the potential for the use of MMPs as a diagnostic tool for assessment of aneurysm development and progression.
Palabras clave
AAA = abdominal aortic aneurysm; ECM = extracellular matrix; IA = intracranial aneurysm; IEL = internal elastic lamina; IL = interleukin; MMP = matrix metalloproteinase; SAH = subarachnoid hemorrhage; TIMP = tissue inhibitor of metalloproteinases; TNFa = tumor necrosis factora; VSMC = vascular smooth muscle cell; WSS = wall shear stress; extracellular matrix; inflammation; intracranial aneurysm; matrix metalloproteinase; vascular remodeling
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aneurisma Intracraneal
/
Metaloproteinasas de la Matriz
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article