Optimization of the traditional processing method for precision detoxification of CaoWu through biomimetic linking kinetics and human toxicokinetics of aconitine as toxic target marker.

Li, Han Qing; Xu, Jia Yin; Fan, Xiao Hong; Wu, Shan Shan

Li, Han Qing; Xu, Jia Yin; Fan, Xiao Hong; Wu, Shan Shan.

Afiliación

Li HQ; State Clinical Trial Institution of New Drugs, International Mongolian Hospital of Inner Mongolia, Hohhot, 010065, China; Mongolian Medicine Laboratory, Mongolian Medicine Institute of Inner Mongolia, Hohhot, 010065, China. Electronic address: hqltcm@163.com.
Xu JY; Mongolian Pharmaceutical Preparation Center, International Mongolian Hospital of Inner Mongolia, Hohhot, 010065, China.
Fan XH; State Clinical Trial Institution of New Drugs, International Mongolian Hospital of Inner Mongolia, Hohhot, 010065, China.
Wu SS; State Clinical Trial Institution of New Drugs, International Mongolian Hospital of Inner Mongolia, Hohhot, 010065, China.

J Ethnopharmacol ; 242: 112053, 2019 Oct 05.

Article en En | MEDLINE | ID: mdl-31271819

Asunto(s)

Aconitina; Aconitum; Modelos Teóricos; Terminalia; Aconitina/análisis; Aconitina/farmacocinética; Aconitina/toxicidad; Animales; Biomimética; Citocinas/metabolismo; Composición de Medicamentos; Humanos; Concentración de Iones de Hidrógeno; Cinética; Ratones; Células RAW 264.7; Conejos; Ratas; Toxicocinética

Palabras clave

Aconitine; Allometric scaling; Detoxification; Kinetics; Processing; Toxicokinetics

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aconitina / Terminalia / Aconitum / Modelos Teóricos Tipo de estudio: Guideline / Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article

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