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Management of epilepsy in brain tumors.
Maschio, Marta; Aguglia, Umberto; Avanzini, Giuliano; Banfi, Paola; Buttinelli, Carla; Capovilla, Giuseppe; Casazza, Marina Maria Luisa; Colicchio, Gabriella; Coppola, Antonietta; Costa, Cinzia; Dainese, Filippo; Daniele, Ornella; De Simone, Roberto; Eoli, Marica; Gasparini, Sara; Giallonardo, Anna Teresa; La Neve, Angela; Maialetti, Andrea; Mecarelli, Oriano; Melis, Marta; Michelucci, Roberto; Paladin, Francesco; Pauletto, Giada; Piccioli, Marta; Quadri, Stefano; Ranzato, Federica; Rossi, Rosario; Salmaggi, Andrea; Terenzi, Riccardo; Tisei, Paolo; Villani, Flavio; Vitali, Paolo; Vivalda, Lucina Carla; Zaccara, Gaetano; Zarabla, Alessia; Beghi, Ettore.
Afiliación
  • Maschio M; Center for Brain Tumor-Related Epilepsy, UOSD Neuro-Oncology, I.R.C.C.S. Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy. marta.maschio@ifo.gov.it.
  • Aguglia U; Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
  • Avanzini G; Department of Neurophysiology and Experimental Epileptology, Carlo Besta Neurological Institute, Milan, Italy.
  • Banfi P; Neurology Unit, Department of Emergency, Medicine Epilepsy Center, Circolo Hospital, Varese, Italy.
  • Buttinelli C; Department of Neuroscience, Mental Health and Sensory Organs, University of Rome "La Sapienza", Rome, Italy.
  • Capovilla G; Department of Mental Health, Epilepsy Center, C. Poma Hospital, Mantua, Italy.
  • Casazza MML; Neurophysiopatology Unit, Fondazione IRCCS, Istituto Neurologico C. Besta, Milan, Italy.
  • Colicchio G; Institute of Neurosurgery, Catholic University of the Sacred Heart, Rome, Italy.
  • Coppola A; Department of Neuroscience, Reproductive and Odontostomatological Sciences, Epilepsy Centre, University of Naples Federico II, Naples, Italy.
  • Costa C; Neurological Clinic, Department of Medicine, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy.
  • Dainese F; Epilepsy Centre, UOC Neurology, SS. Giovanni e Paolo Hospital, Venice, Italy.
  • Daniele O; Epilepsy Center-U.O.C. Neurology, Policlinico Paolo Giaccone, Experimental Biomedicine and Clinical Neuroscience Department (BioNeC), University of Palermo, Palermo, Italy.
  • De Simone R; Neurology and Stroke Unit, Epilepsy and Sleep Disorders Center, St. Eugenio Hospital, Rome, Italy.
  • Eoli M; Molecular Neuro-Oncology Unit, IRCCS-Fondazione Istituto Neurologico Carlo Besta, Milan, Italy.
  • Gasparini S; Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
  • Giallonardo AT; Neurology Unit, Human Neurosciences Department, Sapienza University, Rome, Italy.
  • La Neve A; Department of Neurological and Psychiatric Sciences, Centre for Epilepsy, University of Bari, Bari, Italy.
  • Maialetti A; Center for Brain Tumor-Related Epilepsy, UOSD Neuro-Oncology, I.R.C.C.S. Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.
  • Mecarelli O; Neurology Unit, Human Neurosciences Department, Sapienza University, Umberto 1 Hospital, Rome, Italy.
  • Melis M; Department of Medical Sciences and Public Health, Institute of Neurology, University of Cagliari, Monserrato, Cagliari, Italy.
  • Michelucci R; Unit of Neurology, Bellaria Hospital, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
  • Paladin F; Epilepsy Center, UOC Neurology, Ospedale Santi Giovanni e Paolo, Venice, Italy.
  • Pauletto G; Department of Neurosciences, Santa Maria della Misericordia University Hospital, Udine, Italy.
  • Piccioli M; UOC Neurology, PO San Filippo Neri, ASL Roma 1, Rome, Italy.
  • Quadri S; USC Neurology, Epilepsy Center, ASST Papa Giovanni XXIII, Bergamo, Italy.
  • Ranzato F; Epilepsy Centre, Neuroscience Department, S. Bortolo Hospital, Vicenza, Italy.
  • Rossi R; Neurology and Stroke Unit, San Francesco Hospital, 08100, Nuoro, Italy.
  • Salmaggi A; Neurological Department, ASST, Lecco, Italy.
  • Terenzi R; Epilepsy Consultation Room, Neurology Unit, S. Pietro Fatebenefratelli Hospital, Rome, Italy.
  • Tisei P; Neurophysiology Unit, Department of Neurology-University "La Sapienza", S. Andrea Hospital, Rome, Italy.
  • Villani F; Clinical Epileptology and Experimental Neurophysiology Unit, Fondazione IRCCS, Istituto Neurologico C. Besta, Milan, Italy.
  • Vitali P; Neuroradiology and Brain MRI 3T Mondino Research Center, IRCCS Mondino Foundation, Pavia, Italy.
  • Vivalda LC; Epilepsy Consultation Room, U.O.C. Neurology, Rivoli Hospital, Turin, Italy.
  • Zaccara G; Regional Health Agency of Tuscany, Via P Dazzi 1, 50141, Florence, Italy.
  • Zarabla A; Center for Brain Tumor-Related Epilepsy, UOSD Neuro-Oncology, I.R.C.C.S. Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.
  • Beghi E; Department of Neurosciences, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Neurol Sci ; 40(10): 2217-2234, 2019 Oct.
Article en En | MEDLINE | ID: mdl-31392641
ABSTRACT
Epilepsy in brain tumors (BTE) may require medical attention for a variety of unique concerns epileptic seizures, possible serious adverse effects of antineoplastic and antiepileptic drugs (AEDs), physical disability, and/or neurocognitive disturbances correlated to tumor site. Guidelines for the management of tumor-related epilepsies are lacking. Treatment is not standardized, and overall management might differ according to different specialists. The aim of this document was to provide directives on the procedures to be adopted for a correct diagnostic-therapeutic path of the patient with BTE, evaluating indications, risks, and benefits. A board comprising neurologists, epileptologists, neurophysiologists, neuroradiologists, neurosurgeons, neuro-oncologists, neuropsychologists, and patients' representatives was formed. The board converted diagnostic and therapeutic problems into seventeen questions. A literature search was performed in September-October 2017, and a total of 7827 unique records were retrieved, of which 148 constituted the core literature. There is no evidence that histological type or localization of the brain tumor affects the response to an AED. The board recommended to avoid enzyme-inducing antiepileptic drugs because of their interference with antitumoral drugs and consider as first-choice newer generation drugs (among them, levetiracetam, lamotrigine, and topiramate). Valproic acid should also be considered. Both short-term and long-term prophylaxes are not recommended in primary and metastatic brain tumors. Management of seizures in patients with BTE should be multidisciplinary. The panel evidenced conflicting or lacking data regarding the role of EEG, the choice of therapeutic strategy, and timing to withdraw AEDs and recommended high-quality long-term studies to standardize BTE care.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Epilepsia Tipo de estudio: Guideline Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Epilepsia Tipo de estudio: Guideline Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article