Neonatal clinical blood sampling led to major blood loss and was associated with bronchopulmonary dysplasia.
Acta Paediatr
; 109(4): 679-687, 2020 04.
Article
en En
| MEDLINE
| ID: mdl-31505053
ABSTRACT
AIM:
Studies indicate that reduced foetal haemoglobin levels are related to increased neonatal morbidity rates. This study investigated the relationships between sampling-related blood loss and adult blood transfusions administered during postnatal days 1-14 and the development of severe neonatal morbidities in extremely preterm infants born before 28 weeks of gestation.METHODS:
The medical files of 149 extremely preterm infants born at two university hospitals in Sweden from 2013 to 2018 were investigated.RESULTS:
Blood sampling resulted in a 58% depletion of the endogenous blood volume postnatal days 1-14 (median 40.4 mL/kg, interquartile range 23.9-53.3 mL/kg) and correlated with the adult erythrocyte transfusion volume (rS = 0.870, P < .001). Sampling-related blood loss on postnatal days 1-7, adjusted for gestational age at birth and birth weight standard deviation score, was associated with the development of bronchopulmonary dysplasia (BPD) (odds ratio by a 10-unit increase 2.4, 95% confidence interval 1.1-5.4) (P = .03). No associations were found between blood sampling and intraventricular haemorrhage or necrotising enterocolitis in the full statistical model. The largest proportion of sampling-related blood was used for blood gas analyses (48.7%).CONCLUSION:
Diagnostic blood sampling led to major endogenous blood loss replaced with adult blood components and was associated with the development of BPD.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Displasia Broncopulmonar
/
Enterocolitis Necrotizante
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
/
Infant
/
Newborn
País/Región como asunto:
Europa
Idioma:
En
Año:
2020
Tipo del documento:
Article