Radioresistant laryngeal cancers upregulate type 1 IGF receptor and exhibit increased cellular dependence on IGF and EGF signalling.

Qureishi, Ali; Rieunier, Guillaume; Shah, Ketan A; Aleksic, Tamara; Winter, Stuart C; Møller, Henrik; Macaulay, Valentine M

Qureishi, Ali; Rieunier, Guillaume; Shah, Ketan A; Aleksic, Tamara; Winter, Stuart C; Møller, Henrik; Macaulay, Valentine M.

Afiliación

Qureishi A; Department of Oncology, University of Oxford, Oxford, UK.
Rieunier G; Nuffield Department of Surgery, University of Oxford and Department of Head and Neck Surgery, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, UK.
Shah KA; Department of Oncology, University of Oxford, Oxford, UK.
Aleksic T; Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.
Winter SC; Department of Oncology, University of Oxford, Oxford, UK.
Møller H; Nuffield Department of Surgery, University of Oxford and Department of Head and Neck Surgery, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, UK.
Macaulay VM; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.

Clin Otolaryngol ; 44(6): 1026-1036, 2019 11.

Article en En | MEDLINE | ID: mdl-31536667

Asunto(s)

Carcinoma de Células Escamosas/radioterapia; Factor de Crecimiento Epidérmico/metabolismo; Neoplasias Laríngeas/radioterapia; Receptor IGF Tipo 1/metabolismo; Transducción de Señal/fisiología; Somatomedinas/metabolismo; Anciano; Carcinoma de Células Escamosas/metabolismo; Carcinoma de Células Escamosas/patología; Estudios de Cohortes; Femenino; Humanos; Neoplasias Laríngeas/metabolismo; Neoplasias Laríngeas/patología; Laringectomía; Masculino; Persona de Mediana Edad; Valor Predictivo de las Pruebas; Tolerancia a Radiación

Palabras clave

afatinib; epidermal growth factor receptor; laryngeal squamous cell cancer; radioresistance; radiotherapy; type 1 IGF receptor; xentuzumab

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Somatomedinas / Carcinoma de Células Escamosas / Transducción de Señal / Neoplasias Laríngeas / Receptor IGF Tipo 1 / Factor de Crecimiento Epidérmico Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Año: 2019 Tipo del documento: Article

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