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Safety, tolerability and pharmacokinetics and pharmacodynamics of HL2351, a novel hybrid fc-fused interleukin-1 receptor antagonist, in healthy subjects: A first-in-human study.
Oh, Jaeseong; Huh, Ki Young; Cho, Young-Gyu; Cha, Ji-Eun; Kim, Se-Jin; Yoon, Seo Hyun; Park, Sung Sup; Yoon, Hyunyee; Lee, Jieon; Lee, Howard.
Afiliación
  • Oh J; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.
  • Huh KY; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.
  • Cho YG; Y Biologics, Daejeon, Republic of Korea.
  • Cha JE; HANDOK Inc., Seoul, Republic of Korea.
  • Kim SJ; HANDOK Inc., Seoul, Republic of Korea.
  • Yoon SH; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.
  • Park SS; Department of Laboratory Medicine, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.
  • Yoon H; Protein Immunology Core Facility, Biomedical Research Institutes, Seoul National University Hospital, Seoul, Republic of Korea.
  • Lee J; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.
  • Lee H; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea.
Br J Clin Pharmacol ; 86(2): 372-379, 2020 02.
Article en En | MEDLINE | ID: mdl-31658396
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucocitos Mononucleares / Proteína Antagonista del Receptor de Interleucina 1 Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucocitos Mononucleares / Proteína Antagonista del Receptor de Interleucina 1 Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article