Insulin secretion and sensitivity before and after surgical treatment for aldosterone-producing adenoma.
Diabetes Metab
; 46(3): 236-242, 2020 06.
Article
en En
| MEDLINE
| ID: mdl-31676325
ABSTRACT
AIM:
Primary aldosteronism, which is usually caused by an aldosterone-producing tumour, affects glucose metabolism. The effects of this condition on insulin secretion and insulin sensitivity have remained unclear, however. To gain insight into the influence of primary aldosteronism on glucose tolerance, various parameters related to insulin secretion or insulin sensitivity in patients with an aldosterone-producing tumour were comprehensively analyzed.METHODS:
To assess 14 patients with an aldosterone-producing tumour, hyperglycaemic and hyperinsulinaemic-euglycaemic clamp tests as well as oral glucose tolerance tests (OGTTs) were performed before and after tumour excision. Time between presurgical analysis and surgery was 27-559 (194±132) days, and 14-142 (51±38) days between surgery and postsurgical analysis. Various parameters related to insulin secretion or sensitivity as determined by OGTT as well as hyperglycaemic and hyperinsulinaemic-euglycaemic clamp analyses were evaluated.RESULTS:
Surgical treatment of tumours ameliorated hypokalaemia and reduced plasma aldosterone levels. First and second phases of insulin secretion during the hyperglycaemic clamp, as well as the insulinogenic index and total insulin secretion measured during OGTT, were also improved after surgery. In addition, the insulin sensitivity index determined during the hyperinsulinaemic-euglycaemic clamp was reduced after surgery.CONCLUSION:
Primary aldosteronism impairs insulin secretion.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Resistencia a la Insulina
/
Neoplasias de la Corteza Suprarrenal
/
Adenoma Corticosuprarrenal
/
Aldosterona
/
Secreción de Insulina
/
Hiperaldosteronismo
/
Insulina
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Año:
2020
Tipo del documento:
Article