Your browser doesn't support javascript.
loading
Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence.
Meng, Weida; Sjöholm, Louise K; Kononenko, Olga; Tay, Nicole; Zhang, Dandan; Sarkisyan, Daniil; Geske, Jennifer R; Ing, Alex; Qiu, Wenqing; Watanabe, Hiroyuki; Almamoun, Radwa; Frieling, Helge; Bleich, Stefan; Cui, Donghong; Biernacka, Joanna M; Mayfield, R Dayne; Dang, Yongjun; Karpyak, Victor M; Schumann, Gunter; Bakalkin, Georgy; Ekström, Tomas J; Rüegg, Joelle; Liu, Yun.
Afiliación
  • Meng W; MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Zhongshan Hospital, Fudan University, Shanghai, China.
  • Sjöholm LK; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
  • Kononenko O; Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Tay N; Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
  • Zhang D; Centre for Population Neuroscience and Stratified Medicine (PONS), Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Sarkisyan D; MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Zhongshan Hospital, Fudan University, Shanghai, China.
  • Geske JR; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
  • Ing A; Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
  • Qiu W; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
  • Watanabe H; Centre for Population Neuroscience and Stratified Medicine (PONS), Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Almamoun R; MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Zhongshan Hospital, Fudan University, Shanghai, China.
  • Frieling H; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
  • Bleich S; Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
  • Cui D; Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Biernacka JM; Department of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School, Hannover, Germany.
  • Mayfield RD; Department of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School, Hannover, Germany.
  • Dang Y; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Karpyak VM; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
  • Schumann G; The Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX, USA.
  • Bakalkin G; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
  • Ekström TJ; Centre for Population Neuroscience and Stratified Medicine (PONS), Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Liu Y; Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Mol Psychiatry ; 26(8): 4367-4382, 2021 08.
Article en En | MEDLINE | ID: mdl-31745236
Alcohol misuse is a major public health problem originating from genetic and environmental risk factors. Alterations in the brain epigenome may orchestrate changes in gene expression that lead to alcohol misuse and dependence. Through epigenome-wide association analysis of DNA methylation from human brain tissues, we identified a differentially methylated region, DMR-DLGAP2, associated with alcohol dependence. Methylation within DMR-DLGAP2 was found to be genotype-dependent, allele-specific and associated with reward processing in brain. Methylation at the DMR-DLGAP2 regulated expression of DLGAP2 in vitro, and Dlgap2-deficient mice showed reduced alcohol consumption compared with wild-type controls. These results suggest that DLGAP2 may be an interface for genetic and epigenetic factors controlling alcohol use and dependence.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Consumo de Bebidas Alcohólicas / Metilación de ADN / Epigénesis Genética / Alcoholismo / Proteínas del Tejido Nervioso Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Consumo de Bebidas Alcohólicas / Metilación de ADN / Epigénesis Genética / Alcoholismo / Proteínas del Tejido Nervioso Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article