Identification of human lactate dehydrogenase A inhibitors with anti-osteosarcoma activity through cell-based phenotypic screening.

Wang, Fei; Zhao, Qiheng; Liu, Junzhi; Wang, Zhe; Kong, Daliang

Wang, Fei; Zhao, Qiheng; Liu, Junzhi; Wang, Zhe; Kong, Daliang.

Afiliación

Wang F; Department of Orthopaedics, Jilin University China-Japan Union Hospital, Jilin 130030, China.
Zhao Q; Department of Orthopaedics, Jilin University China-Japan Union Hospital, Jilin 130030, China.
Liu J; Department of Quality Control, Jilin University China-Japan Union Hospital, Jilin 130030, China.
Wang Z; Department of Pathology, School of Basic Medicine, Jilin University, Jilin 130000, China.
Kong D; Department of Orthopaedics, Jilin University China-Japan Union Hospital, Jilin 130030, China. Electronic address: Daliangkong@hotmail.com.

Bioorg Med Chem Lett ; 30(4): 126909, 2020 02 15.

Article en En | MEDLINE | ID: mdl-31879209

Asunto(s)

Inhibidores Enzimáticos/química; L-Lactato Deshidrogenasa/antagonistas & inhibidores; Sitios de Unión; Dominio Catalítico; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Inhibidores Enzimáticos/metabolismo; Inhibidores Enzimáticos/farmacología; Humanos; L-Lactato Deshidrogenasa/metabolismo; Simulación del Acoplamiento Molecular; Osteosarcoma/metabolismo; Osteosarcoma/patología

Palabras clave

Anticancer; Cancer metabolism; Glycolysis; Lactate dehydrogenase A

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores Enzimáticos / L-Lactato Deshidrogenasa Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google