Management of brain metastases in breast cancer: a review of current practices and emerging treatments.
Breast Cancer Res Treat
; 180(2): 279-300, 2020 Apr.
Article
en En
| MEDLINE
| ID: mdl-32030570
ABSTRACT
PURPOSE:
Breast cancer brain metastases (BCBM) are becoming an increasingly common diagnosis due to improved systemic control and more routine surveillance imaging. Treatment continues to require a multidisciplinary approach managing systemic and intracranial disease burden. Although, improvements have been made in the diagnosis and management of BCBM, brain metastasis patients continue to pose a challenge for practitioners.METHODS:
In this review, a group of medical oncologists, radiation oncologists, radiologists, breast surgeons, and neurosurgeons specializing in the treatment of breast cancer reviewed the available published literature and compiled a comprehensive review on the current state of BCBM.RESULTS:
We discuss the pathogenesis, epidemiology, diagnosis, treatment options (including systemic, surgical, and radiotherapy treatment modalities), and treatment response evaluation for BCBM. Furthermore, we discuss the ongoing prospective trials enrolling BCBM patients and their biologic rationale.CONCLUSIONS:
BCBM management is an increasing clinical concern. Multidisciplinary management combining the strengths of surgical, systemic, and radiation treatment modalities with prospective trials incorporating knowledge from the basic and translational sciences will ultimately lead to improved clinical outcomes for BCBM patients.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pautas de la Práctica en Medicina
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Neoplasias Encefálicas
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Neoplasias de la Mama
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Terapia Molecular Dirigida
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Inmunoterapia
Límite:
Female
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Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article