The heme biosynthetic pathway in lymphocytes of patients with malignant lymphoproliferative disorders.
Cancer Lett
; 43(1-2): 43-8, 1988 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-3203329
ABSTRACT
The metabolism of heme is impaired in lymphocytes of patients with malignant lymphoproliferative disorders (MLPO). Two of the enzymes of the heme biosynthetic pathway, delta-aminolevulinic acid dehydrase (ALAD) (EC 4.2.1.24) and ferrochelatase (FC) (EC 4.99.1.1) are markedly reduced. The activity of porphobilinogen deaminase (PBGD) (EC 4.3.1.8) is increased. The rate-limiting enzyme of heme biosynthesis in the liver, aminolevulinate synthase (ALAS) (EC 2.3.1.37) remains unchanged although the concentration of total heme in the lymphocytes is markedly reduced. This might reflect a lack of negative feedback inhibition by heme on ALAS activity in this system.
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Banco de datos:
MEDLINE
Asunto principal:
Linfocitos
/
Hemo
/
Trastornos Linfoproliferativos
Límite:
Humans
Idioma:
En
Año:
1988
Tipo del documento:
Article