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Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis.
Lefebvre, Cyril; Frigui, Wafa; Slama, Nawel; Lauzeral-Vizcaino, Françoise; Constant, Patricia; Lemassu, Anne; Parish, Tanya; Eynard, Nathalie; Daffé, Mamadou; Brosch, Roland; Quémard, Annaïk.
Afiliación
  • Lefebvre C; Département Tuberculose & Biologie des Infections, Institut de Pharmacologie et de Biologie Structurale, UMR5089, Université de Toulouse, CNRS, UPS, 31077, Toulouse, Cedex 04, France.
  • Frigui W; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.
  • Slama N; Département Tuberculose & Biologie des Infections, Institut de Pharmacologie et de Biologie Structurale, UMR5089, Université de Toulouse, CNRS, UPS, 31077, Toulouse, Cedex 04, France.
  • Lauzeral-Vizcaino F; Toulouse White Biotechnology (UMS INRA / INSA / CNRS), Ramonville Saint-Agne, France.
  • Constant P; Département Tuberculose & Biologie des Infections, Institut de Pharmacologie et de Biologie Structurale, UMR5089, Université de Toulouse, CNRS, UPS, 31077, Toulouse, Cedex 04, France.
  • Lemassu A; Centre de Recherches en Cancérologie de Toulouse, UMR1037 Inserm/UPS, Toulouse, France.
  • Parish T; Département Tuberculose & Biologie des Infections, Institut de Pharmacologie et de Biologie Structurale, UMR5089, Université de Toulouse, CNRS, UPS, 31077, Toulouse, Cedex 04, France.
  • Eynard N; Département Tuberculose & Biologie des Infections, Institut de Pharmacologie et de Biologie Structurale, UMR5089, Université de Toulouse, CNRS, UPS, 31077, Toulouse, Cedex 04, France.
  • Daffé M; TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA.
  • Brosch R; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
  • Quémard A; Département Tuberculose & Biologie des Infections, Institut de Pharmacologie et de Biologie Structurale, UMR5089, Université de Toulouse, CNRS, UPS, 31077, Toulouse, Cedex 04, France.
Sci Rep ; 10(1): 2112, 2020 02 07.
Article en En | MEDLINE | ID: mdl-32034201
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Virulencia / Acido Graso Sintasa Tipo II / Mycobacterium tuberculosis / Ácidos Micólicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Virulencia / Acido Graso Sintasa Tipo II / Mycobacterium tuberculosis / Ácidos Micólicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article