Acute In Vivo Functional Assessment of a Biodegradable Stentless Elastomeric Tricuspid Valve.
J Cardiovasc Transl Res
; 13(5): 796-805, 2020 10.
Article
en En
| MEDLINE
| ID: mdl-32040766
ABSTRACT
Degradable heart valves based on in situ tissue regeneration have been proposed as potentially durable and non-thrombogenic prosthetic alternatives. We evaluated the acute in vivo function, microstructure, mechanics, and thromboresistance of a stentless biodegradable tissue-engineered heart valve (TEHV) in the tricuspid position. Biomimetic stentless tricuspid valves were fabricated with poly(carbonate urethane)urea (PCUU) by double-component deposition (DCD) processing to mimic native valve mechanics and geometry. Five swine then underwent 24-h TEHV implantation in the tricuspid position. Echocardiography demonstrated good leaflet motion and no prolapse and trace to mild regurgitation in all but one animal. Histology revealed patches of proteinaceous deposits with no cellular uptake. SEM demonstrated retained scaffold microarchitecture with proteinaceous deposits but no platelet aggregation or thrombosis. Explanted PCUU leaflet thickness and mechanical anisotropy were comparable with native tricuspid leaflets. Bioinspired, elastomeric, stentless TEHVs fabricated by DCD were readily implantable and demonstrated good acute function in the tricuspid position.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Poliuretanos
/
Válvula Tricúspide
/
Prótesis Valvulares Cardíacas
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Implantación de Prótesis de Válvulas Cardíacas
/
Elastómeros
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Año:
2020
Tipo del documento:
Article