Tolerance of cyclosporine A in children with refractory juvenile rheumatoid arthritis.
J Rheumatol
; 15(10): 1536-8, 1988 Oct.
Article
en En
| MEDLINE
| ID: mdl-3204600
ABSTRACT
In an open trial, tolerance and safety of cyclosporine A was studied in 14 patients with refractory juvenile rheumatoid arthritis (JRA). The doses varied from 4-15 mg/kg/day. Treatment lasted for greater than 12 months in 11 and 6 to 9 months in 3 patients. Eleven patients were withdrawn due to lack of efficacy (4) or side effects (7). A drop of greater than 2 g/l in hemoglobin and a marked rise in serum creatinine were the cause of withdrawal in 5 patients. The effect of cyclosporine on disease activity seemed to be mainly symptomatic and temporary. Probably, the dose should be kept below 5 mg/kg/day. Future controlled studies should be aware of a risk of aggravation of anemia in children treated with cyclosporine.
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Banco de datos:
MEDLINE
Asunto principal:
Artritis Juvenil
/
Ciclosporinas
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Año:
1988
Tipo del documento:
Article