Your browser doesn't support javascript.
loading
Moesin facilitates metastasis of hepatocellular carcinoma cells by improving invadopodia formation and activating ß-catenin/MMP9 axis.
Lan, Shubing; Zheng, Xiaoyuan; Hu, Ping; Xing, Xiaohua; Ke, Kun; Wang, Fei; Cheng, Niangmei; Zhuang, Qiuyu; Liu, Xiaolong; Liu, Jingfeng; Zhao, Bixing; Wang, Yingchao.
Afiliación
  • Lan S; College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, PR China; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, PR China; Fujian
  • Zheng X; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, PR China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian, 350025, PR China.
  • Hu P; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, PR China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian, 350025, PR China.
  • Xing X; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, PR China; Mengchao Med-X Center, Fuzhou University, Fuzhou, Fujian, 350116, PR China; The Liver Center of Fujian Provinc
  • Ke K; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, PR China; Mengchao Med-X Center, Fuzhou University, Fuzhou, Fujian, 350116, PR China.
  • Wang F; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, PR China; Mengchao Med-X Center, Fuzhou University, Fuzhou, Fujian, 350116, PR China.
  • Cheng N; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, PR China; Mengchao Med-X Center, Fuzhou University, Fuzhou, Fujian, 350116, PR China.
  • Zhuang Q; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, PR China; Mengchao Med-X Center, Fuzhou University, Fuzhou, Fujian, 350116, PR China; The Liver Center of Fujian Provinc
  • Liu X; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, PR China; Mengchao Med-X Center, Fuzhou University, Fuzhou, Fujian, 350116, PR China; The Liver Center of Fujian Provinc
  • Liu J; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, PR China; Mengchao Med-X Center, Fuzhou University, Fuzhou, Fujian, 350116, PR China; The Liver Center of Fujian Provinc
  • Zhao B; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, PR China; Mengchao Med-X Center, Fuzhou University, Fuzhou, Fujian, 350116, PR China; The Liver Center of Fujian Provinc
  • Wang Y; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, PR China; Mengchao Med-X Center, Fuzhou University, Fuzhou, Fujian, 350116, PR China; The Liver Center of Fujian Provinc
Biochem Biophys Res Commun ; 524(4): 861-868, 2020 04 16.
Article en En | MEDLINE | ID: mdl-32057364
ABSTRACT
Moesin has been proved to be implicated in invasiveness and metastasis in many other cancers, but unclear in HCC. Thus, this study was performed to investigate the clinical significance of moesin and its biological functions in HCC. The results showed that moesin was significantly up-regulated in HCC tissues and was an independent prognostic factor for predicting the recurrence of HCC patients, postoperatively. Furthermore, we also demonstrated that moesin promoted the migration and invasion of HCC cells in vitro and in vivo. And the mechanism studies indicated that moesin overexpression increased the formation of invadopodia and improved the activation of ß-catenin/MMP9 axis. Taken together, our findings revealed that moesin acted as an important onco-protein participating in the metastasis of HCC.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Carcinoma Hepatocelular / Metaloproteinasa 9 de la Matriz / Beta Catenina / Neoplasias Hepáticas / Recurrencia Local de Neoplasia Tipo de estudio: Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Carcinoma Hepatocelular / Metaloproteinasa 9 de la Matriz / Beta Catenina / Neoplasias Hepáticas / Recurrencia Local de Neoplasia Tipo de estudio: Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Article