CAR T-Cell-Associated Neurotoxicity: Current Management and Emerging Treatment Strategies.
Crit Care Nurs Q
; 43(2): 191-204, 2020.
Article
en En
| MEDLINE
| ID: mdl-32084062
ABSTRACT
Axicabtagene ciloleucel and tisagenlecleucel are 2 chimeric antigen receptor (CAR) T-cell immunotherapies targeting CD19 for the treatment of B-cell acute lymphoblastic leukemia and non-Hodgkin lymphoma. Two commonly recognized complications associated with CAR T-cell therapies are cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). ICANS can occur in isolation or concomitantly with CRS following CAR T-cell therapy and may be due to disruption of the blood-brain barrier and the effects of elevated cytokine levels on the central nervous system. Presently, the optimum management of ICANS remains elusive, as there lacks consensus guidelines. The objective of this review is to provide a comprehensive summary of ICANS and strategies for prompt identification and management of patients presenting to the intensive care unit with this syndrome.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfoma no Hodgkin
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Leucemia Linfocítica Crónica de Células B
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Inmunoterapia Adoptiva
/
Antígenos CD19
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Síndromes de Neurotoxicidad
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Síndrome de Liberación de Citoquinas
Tipo de estudio:
Guideline
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article