An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease.
Br J Haematol
; 189(5): 926-930, 2020 06.
Article
en En
| MEDLINE
| ID: mdl-32086815
ABSTRACT
We previously reported a protective association between single nucleotide polymorphisms (SNPs; rs4415345G and rs4610776A alleles) of Paneth cell α-defensin-5 against acute graft-versus-host disease (aGVHD). Because dysbiosis has been associated with aGVHD, we hypothesized that these SNPs may have a gut microbiota signature. In Lasso regression analysis of 248 healthy individuals, rs4415345G was associated with a higher abundance of Odoribacter splanchnicus, an anaerobic butyrogenic commensal. In multivariable analysis of data from 613 allogeneic haematopoietic cell transplant recipients, peri-engraftment presence of O. splanchnicus was associated with ~50% lower risk for grade II-IV aGVHD (hazard ratio 0·53, 95% confidence interval 0·28-1·00, P = 0·05). O. splanchnicus may protect rs4415345G individuals against aGVHD.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células de Paneth
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Polimorfismo de Nucleótido Simple
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Alfa-Defensinas
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Bacteroidetes
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Disbiosis
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Microbioma Gastrointestinal
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Enfermedad Injerto contra Huésped
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Año:
2020
Tipo del documento:
Article