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Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.
Miyauchi, Yuu; Kurita, Ayumi; Yamashita, Ryohei; Takamatsu, Tomoyuki; Ikushiro, Shin'ichi; Mackenzie, Peter I; Tanaka, Yoshitaka; Ishii, Yuji.
Afiliación
  • Miyauchi Y; Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
  • Kurita A; Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
  • Yamashita R; Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
  • Takamatsu T; Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
  • Ikushiro S; Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Izumi, Toyama, Japan.
  • Mackenzie PI; Clinical Pharmacology, College of Medicine and Public Health, Flinders Medical Centre and Flinders University, Adelaide, Australia.
  • Tanaka Y; Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
  • Ishii Y; Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan; Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: ishii@phar.kyushu-u.ac.jp.
Biochem Biophys Res Commun ; 525(2): 348-353, 2020 04 30.
Article en En | MEDLINE | ID: mdl-32093886
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glucuronosiltransferasa / Multimerización de Proteína / Morfina Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glucuronosiltransferasa / Multimerización de Proteína / Morfina Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article