Micronucleus Assay: The State of Art, and Future Directions.
Int J Mol Sci
; 21(4)2020 Feb 24.
Article
en En
| MEDLINE
| ID: mdl-32102335
ABSTRACT
During almost 40 years of use, the micronucleus assay (MN) has become one of the most popular methods to assess genotoxicity of different chemical and physical factors, including ionizing radiation-induced DNA damage. In this minireview, we focus on the position of MN among the other genotoxicity tests, its usefulness in different applications and visibility by international organizations, such as International Atomic Energy Agency, Organization for Economic Co-operation and Development and International Organization for Standardization. In addition, the mechanism of micronuclei formation is discussed. Finally, foreseen directions of the MN development are pointed, such as automation, buccal cells MN and chromothripsis phenomenon.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos
/
Pruebas de Micronúcleos
/
Micronúcleos con Defecto Cromosómico
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Pruebas de Mutagenicidad
/
Mutágenos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article