Successful Combination of Landiolol and Levosimendan in Patients with Decompensated Heart Failure.
Int Heart J
; 61(2): 384-389, 2020 Mar 28.
Article
en En
| MEDLINE
| ID: mdl-32132321
ABSTRACT
Tachycardia and supraventricular tachyarrhythmias often impair cardiovascular capacity in patients with decompensated heart failure (dHF) treated with inotropes. Normalization of heart rhythm or rate typically improves diastolic filling and stroke volume (SV). Thus, isochronal administration of an ultra-short-acting and highly selective ß1-blockers, such as landiolol, along with inotropic calcium-sensitizer medications, such as levosimendan, could benefit patients with dHF.We present a case series of three patients with severe dHF and low ejection fraction who were successfully treated with a combination of landiolol and levosimendan. The co-administration of landiolol and levosimendan was well tolerated, improved cardiac function, normalized SV, and enabled the reduction of norepinephrine dosing in all patients. Additionally, the combination improved the vectorcardiographic spatial QRS-T angle and decreased the corrected QT interval. All patients were successfully discharged from the intensive care unit (ICU).A combination of levosimendan and landiolol was safe and well-tolerated. This combination may be a new option for successful treatment of patients with acute dHF complicated by sinus or supraventricular tachycardias.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Taquicardia
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Urea
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Cardiotónicos
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Morfolinas
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Antagonistas Adrenérgicos beta
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Simendán
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Insuficiencia Cardíaca
Tipo de estudio:
Etiology_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Año:
2020
Tipo del documento:
Article