Transversus abdominis plane block versus quadratus lumborum block type 2 for analgesia in renal transplantation: A randomised trial.
Eur J Anaesthesiol
; 37(9): 773-789, 2020 Sep.
Article
en En
| MEDLINE
| ID: mdl-32175985
ABSTRACT
BACKGROUND:
Several studies have shown an analgesic efficacy of a transversus abdominis plane block (TAPB) in reducing opioid requirements during and after cadaveric renal transplantation surgery, but the effect of a quadratus lumborum block (QLB) in this type of surgery is unclear.OBJECTIVES:
The main objective of this prospective, randomised, double-centre clinical study was to compare the analgesic efficacy of a one-sided lateral approach TAPB with a unilateral QLB type 2 in cadaveric renal transplantation surgery.DESIGN:
Randomised, single-blinded trial.SETTING:
Two University-affiliated tertiary care hospitals between April 2016 and May 2017. PATIENTS A total of 101 patients aged more than 18 years, scheduled for cadaveric renal transplantation.INTERVENTIONS:
On receiving ethical board approval and individual informed consent, consecutive patients were allocated randomly to receive either an ultrasound-guided single-shot lateral TAPB or an ultrasound-guided single-shot QLB type 2 on the surgical side using 20âml of bupivacaine 0.25% with adrenaline after a standardised induction of general anaesthesia. All patients on surgical completion and recovery from general anaesthesia were admitted to the postanaesthesia care unit for 24âh. They received standardised intravenous patient-controlled analgesia with fentanyl, and their pain scores were noted at regular intervals. MAIN OUTCOMEMEASURES:
The primary endpoint was total cumulative fentanyl dose used per kg body mass in the first 24âh after surgery. Secondary outcomes were the need to start a continuous infusion of fentanyl in addition to patient-controlled analgesia boluses during the stay in post-anaesthesia care unit, postoperative pain severity measured using a numerical rating scale, patient satisfaction with analgesic treatment, evidence of postoperative nausea and vomiting, pruritus and sedation level.RESULTS:
The 49 patients allocated to the QLB type 2 group used significantly less fentanyl per kg in the first 24âh after surgery than the 52 patients who received a TAPB (median [IQR] 4.2 [2.3 to 8.0]âµgâkg versus 6.7 [3.5 to 10.7]âµgâkg, Pâ=â0.042). No statistically significant differences were noted in the secondary endpoints within the study, including the frequency of adverse effects of opioids.CONCLUSION:
The reduction of fentanyl consumption in the first 24âh after renal transplantation with no difference in pain intensity and patient satisfaction shows a beneficial effect of one-sided QLB type 2 over a one-sided TAPB in regards to postoperative analgesia. However, the reduction in opioid consumption did not affect the frequency of opioid-related adverse effects. TRIAL REGISTRATION ClinicalTrials.gov ID NCT02783586.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Riñón
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
Límite:
Aged
/
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article