Myo-inositol impact on sperm motility in vagina and evaluation of its effects on foetal development.
Eur Rev Med Pharmacol Sci
; 24(5): 2704-2709, 2020 03.
Article
en En
| MEDLINE
| ID: mdl-32196621
ABSTRACT
OBJECTIVE:
To counteract the arising problem of couple infertility, having good quality gametes is increasingly important. A molecule that seems to be useful to favor this condition is myo-inositol (MI), the most common stereoisomer of the inositol family, involved as second messenger in several cell pathways (osmoregulation, chromatin remodeling, gene expression, etc.). To evaluate this possibility, a treatment with myo-inositol in idiopathic infertile couples was performed in this randomized, placebo-controlled study. PATIENTS ANDMETHODS:
86 couples were enrolled and randomly assigned to two groups, treated either with MI (Xyminal®, Lo.Li. Pharma Srl, Rome, Italy) or placebo suppositories, to evaluate the effects on sperm motility, cervical mucus quality and pregnancy rate. Moreover, in pregnancy cases, all routine controls on gestation progress and foetal health were performed to confirm the safety of this treatment.RESULTS:
As showed in this study, MI treatment allows an increase of total sperm motility (54.42 ± 8.72) in comparison to placebo group (46.21 ± 5.33). Moreover, MI mildly improves cervical mucus quality and increases the number of pregnancies (18.60%) in comparison to the placebo group (6.97%).CONCLUSIONS:
MI improves sperm motility and cervical mucus quality, increasing the probability of conception. The absence of adverse events both for the mother and the foetus confirmed the safety of this molecule in pregnancy, supporting even more its use for couples seeking pregnancy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Motilidad Espermática
/
Espermatozoides
/
Desarrollo Fetal
/
Infertilidad
/
Inositol
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
País/Región como asunto:
Europa
Idioma:
En
Año:
2020
Tipo del documento:
Article